Chapter 1: Ground Zeroes
* Summary: The game opens with a prologue mission in which Venom Snake, the protagonist, infiltrates a US military black site in Cuba to rescue Paz Ortega Andrade and Chico Mendez.
* Real Example: Venom Snake uses stealth and subterfuge to avoid detection and eliminate enemy guards, demonstrating the game's emphasis on strategic gameplay.
Chapter 2: A Phantom Limb
* Summary: Snake awakens from a nine-year coma and discovers that he has lost his left arm and been replaced by a bionic limb. He travels to Cyprus to find his former mentor, Ocelot, and learn about the events that transpired during his absence.
* Real Example: Snake undergoes a series of rehabilitation exercises to regain control of his new arm, showcasing the game's focus on player skill and adaptability.
Chapter 3: The Phantom Pain
* Summary: Snake establishes the Diamond Dogs, a private military company, to investigate the identity of Skull Face, the leader of the mercenary group XOF who played a role in Snake's coma.
* Real Example: Snake recruits soldiers and develops new weapons and technologies, demonstrating the game's emphasis on resource management and customization.
Chapter 4: Eli
* Summary: Snake investigates a child soldier named Eli who possesses the ability to control parasites. He confronts XOF in Afghanistan and learns about their plans to use Eli's powers for biological warfare.
* Real Example: Snake engages in tense firefights and encounters challenging boss battles, demonstrating the game's engaging combat mechanics.
Chapter 5: Code Talker
* Summary: Snake recruits Code Talker, a Navajo linguist with knowledge of the parasite language. They infiltrate the Skull Face's fortress in Africa to uncover his motivations and prevent the spread of the parasite.
* Real Example: Snake solves puzzles and overcomes environmental challenges, showcasing the game's diverse gameplay elements.
Chapter 6: Truth
* Summary: Snake confronts Skull Face and learns the truth about his past and the nature of the parasite. He defeats Skull Face and disbands XOF, but not before discovering that Eli has escaped with Code Talker.
* Real Example: Snake engages in a climactic boss battle that tests his skills and resolves the game's central narrative conflict.
Chapter 7: Kingdom of the Flies
* Summary: Venom Snake investigates Sahelanthropus, a bipedal nuclear weapon, which has been stolen by Eli and Code Talker. He travels to Afghanistan to prevent its detonation and confront Eli's motives.
* Real Example: Snake conducts reconnaissance missions and infiltrates hostile territory, showcasing the game's stealth and espionage elements.
Chapter 8: Phantom
* Summary: Snake finally confronts Eli at the Sahelanthropus launch site. The truth about Venom Snake's identity and the purpose of the Diamond Dogs is revealed.
* Real Example: Snake engages in an emotional and thought-provoking dialogue sequence that concludes the game's story and leaves open-ended questions for the future.